She was given a role as Mathilde in the 2008 autonomous film The Loss of a Teardrop Diamond, featuring Bryce Dallas Howard, Chris Evans, Ellen Burstyn, Ann-Margret, Will Patton, Mamie Gummer, and Jessica Collins.

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In 2016, Zoe rejuvenated the personality of Jane, Doug Anderson’s pregnant sweetheart, in the secret spine chiller TV series The Family. She assumed the common part of Samantha Ruland in the political spine chiller show TV series Scandal in 2017. In 2017, Zoe Perry began showing up as Mary Tucker Cooper, Sheldon, Missy, and Georgie’s mom who is a passionate Southern Baptist and is extremely defensive and patient with Sheldon, in the transitioning sitcom TV series Young Sheldon.

It is a side project prequel to The Big Bang Theory and the personality of Mary Tucker Cooper was started by Zoe’s mom, Laurie Metcalf, in The Big Bang Theory.As a theater entertainer, she has been projected in projects including The Late Christopher Bean, Anna Christie, The Other Place, The Lieutenant of Inishmore, End Days, Peace in Our Time, Good Television, The Way West, I’ll Get You Back Again, and The Autumn Garden.